EXTRACTION AND ISOLATION OF INDOLE ALKALOIDS FROM Tabernaemontana catharinensis: TECHNICAL AND ECONOMICAL ANALYSIS
نویسندگان
چکیده
Leishmaniasis is a parasitic infection that is considered worldwide one of the most important public health problem, affecting more than 12 million people with an estimated number of 2 million new cases occurring annually. Among the compounds isolated from Tabernaemontana catharinensis, coronaridine and voacangine are the indole alkaloids which have antileishmanial activity. In this work, the technical and economical analysis of extraction and isolation of indole alkaloids from Tabernaemontana catharinensis is presented. The extraction was carried out using supercritical CO2 as solvent and ethanol as cosolvent (9.2% m/m). The data were taken total solvent flow rate of 6.1 ×10 kg/s, pressures of 300 bar and temperature of 318.15 K. The extracts were fractionated and analyzed by Thin-layer chromatography and Gas-chromatography/Mass Spectrometry. The economical analysis was carried out considering that the cost of manufacturing can be obtained in terms of the costs of investment, operational labor, raw material, waste treatment and utilities.
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تاریخ انتشار 2003